Lisinopril/hydrochlorothiazide

Lisinopril/hydrochlorothiazide
Combination of
LisinoprilACE inhibitor
HydrochlorothiazideThiazide diuretic
Names
Trade namesZestoretic, Prinzide, others
Clinical data
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • US: D (Evidence of risk)
    Routes of
    use    		By mouth
    Defined daily dosenot established[1]
    External links
    AHFS/Drugs.comMultum Consumer Information
    MedlinePlusa601070
    Legal
    Legal status
    • In general: ℞ (Prescription only)

    Lisinopril/hydrochlorothiazide, sold under the trade name Zestoretic among others, is a combination of the medications lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic.[2] It is used to treat high blood pressure.[2] Typically, it becomes an option once a person is doing well on the individual components.[3] It is taken by mouth.[2]

    Common side effects include dizziness, headache, cough, and feeling tired.[4] Severe side effects may include angioedema and low blood pressure.[4] Use during pregnancy may harm the baby.[4]

    The combination was approved for medical use in the United States in 1989.[2] It is on the World Health Organization's List of Essential Medicines.[5] It is available as a generic medication.[3] In the United States the wholesale cost per dose is less than US$0.05 as of 2018.[6] In the United Kingdom it costs the NHS about GB£0.40 per dose as of 2017.[3] In 2017, it was the 44th most commonly prescribed medication in the United States, with more than 16 million prescriptions.[7][8]

    Dosage

    The defined daily dose is not established.[1]

    Society and culture

    Cost

    In the United States the wholesale cost per dose is less than US$0.05 as of 2018.[6]In the United Kingdom it costs the NHS about GB£0.40 per dose as of 2017.[3] In 2017, it was the 44th most commonly prescribed medication in the United States, with more than 16 million prescriptions.[7][8]

    References

    1. 1 2 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2021. Retrieved 9 September 2020.
    2. 1 2 3 4 "Hydrochlorothiazide and lisinopril Uses, Side Effects & Warnings". Drugs.com. Cerner Multum. Archived from the original on 28 June 2019. Retrieved 26 December 2018.
    3. 1 2 3 4 British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. 166. ISBN 978-0857112989.
    4. 1 2 3 "Lisinopril and Hydrochlorothiazide - FDA prescribing information, side effects and uses". Drugs.com. Solco Healthcare LLC. Archived from the original on 18 April 2019. Retrieved 26 December 2018.
    5. ↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
    6. 1 2 "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services. Archived from the original on 19 December 2018. Retrieved 22 December 2018.
    7. 1 2 "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
    8. 1 2 "Hydrochlorothiazide; Lisinopril - Drug Usage Statistics". ClinCalc. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
    Identifiers:



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